已入深夜,您辛苦了!由于当前在线用户较少,发布求助请尽量完整的填写文献信息,科研通机器人24小时在线,伴您度过漫漫科研夜!祝你早点完成任务,早点休息,好梦!

NT-proBNP and Cardiac Troponin I, but Not Cardiac Troponin T, Are Associated With 7-Year Changes in Cardiac Structure and Function in Older Adults: The ARIC Study

医学 内科学 心脏病学 射血分数 利钠肽 肌钙蛋白I 心力衰竭 肌钙蛋白 队列 肌钙蛋白T 肾功能 心功能曲线 前瞻性队列研究 体质指数 心肌梗塞
作者
Peder L. Myhre,Brian Claggett,Christie M. Ballantyne,Ron C. Hoogeveen,Elizabeth Selvin,Kunihiro Matsushita,Dalane W. Kitzman,Suma Konety,Thomas H. Mosley,Amil M. Shah
出处
期刊:Circulation [Ovid Technologies (Wolters Kluwer)]
标识
DOI:10.1161/circulationaha.124.069735
摘要

BACKGROUND: Higher circulating concentrations of NT-proBNP (N-terminal pro-B-type natriuretic peptide) and high-sensitivity cardiac troponin T (hs-cTnT) and I (hs-cTnI) are associated with left ventricular remodeling and with incident heart failure. The associations of these cardiac biomarkers with changes in cardiac structure and function over time are uncharacterized. METHODS: Among 2006 participants in the ARIC prospective cohort study (Atherosclerosis Risk in Communities) who were free of overt cardiovascular disease and underwent echocardiography at study visits 5 (2011– 2013) and 7 (2018–2019), we assessed the associations of NT-proBNP, hs-cTnT, and hs-cTnI concentrations at visit 5 with changes in left ventricular structure and function between visits 5 and 7 (≈7-year change) using multivariable linear regression with the biomarkers modeled as restricted cubic splines. Models were adjusted for age, sex, race, body mass index, smoking, diabetes, hypertension, and renal function at visit 5; blood pressure and heart rate at both visits; and the baseline value of the echocardiographic parameter of interest. RESULTS: Mean±SD age was 74±4 years at visit 5; 61% were women; and 23% were Black adults. Median (25th–75th percentile) concentrations at visit 5 of NT-proBNP, hs-cTnT, and hs-cTnI were 87 ng/L (50–157 ng/L), 9 ng/L (6–12 ng/L), and 2.6 ng/L (1.9–3.9 ng/L). In adjusted models, elevated baseline concentrations of NT-proBNP and hs-cTnI were significantly associated with 7-year decline in left ventricular systolic function (ejection fraction, longitudinal and circumferential strain) and worsening diastolic indices. In contrast, elevated baseline concentrations of hs-cTnT were not significantly associated with 7-year changes in cardiac structure, systolic function, or diastolic function (all P >0.05). CONCLUSIONS: Higher concentrations of NT-proBNP and hs-cTnI, but not hs-cTnT, were associated with greater declines in left ventricular function over ≈7 years in late life independently of traditional cardiovascular risk factors.AQ
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
大幅提高文件上传限制,最高150M (2024-4-1)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
刚刚
刚刚
2秒前
3秒前
希望天下0贩的0应助康2000采纳,获得10
5秒前
董竹君发布了新的文献求助10
6秒前
kjding发布了新的文献求助10
8秒前
zwww发布了新的文献求助10
8秒前
chen发布了新的文献求助10
10秒前
14秒前
star完成签到 ,获得积分10
14秒前
17秒前
20秒前
jyw发布了新的文献求助10
23秒前
调研昵称发布了新的文献求助10
23秒前
27秒前
WY发布了新的文献求助10
27秒前
28秒前
31秒前
一一应助小陈要发一区采纳,获得10
31秒前
小胖子发布了新的文献求助10
32秒前
饱满的百招完成签到 ,获得积分10
35秒前
追寻半仙完成签到 ,获得积分10
36秒前
gjww应助WY采纳,获得10
39秒前
40秒前
zhukeqinag完成签到,获得积分10
40秒前
ding应助zwww采纳,获得10
44秒前
Coral.完成签到,获得积分10
46秒前
49秒前
Coral.发布了新的文献求助20
49秒前
楚天阔发布了新的文献求助10
50秒前
昂口3完成签到 ,获得积分10
54秒前
小白又鹏发布了新的文献求助10
54秒前
54秒前
潇湘完成签到 ,获得积分10
58秒前
59秒前
1分钟前
田様应助小白又鹏采纳,获得10
1分钟前
李晨阳发布了新的文献求助10
1分钟前
科研通AI2S应助润森采纳,获得10
1分钟前
高分求助中
The ACS Guide to Scholarly Communication 2500
Sustainability in Tides Chemistry 2000
Pharmacogenomics: Applications to Patient Care, Third Edition 1000
Studien zur Ideengeschichte der Gesetzgebung 1000
TM 5-855-1(Fundamentals of protective design for conventional weapons) 1000
Threaded Harmony: A Sustainable Approach to Fashion 810
《粉体与多孔固体材料的吸附原理、方法及应用》(需要中文翻译版,化学工业出版社,陈建,周力,王奋英等译) 500
热门求助领域 (近24小时)
化学 医学 生物 材料科学 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 基因 遗传学 催化作用 物理化学 免疫学 量子力学 细胞生物学
热门帖子
关注 科研通微信公众号,转发送积分 3084988
求助须知:如何正确求助?哪些是违规求助? 2738035
关于积分的说明 7547906
捐赠科研通 2387624
什么是DOI,文献DOI怎么找? 1266055
科研通“疑难数据库(出版商)”最低求助积分说明 613267
版权声明 598450