编码(社会科学)
生物
长非编码RNA
癌症研究
计算生物学
计算机科学
核糖核酸
社会学
基因
遗传学
社会科学
作者
Ming-Yuan Cao,Zhendong Zhang,Xin-Rui Hou,Xiaoping Wang
出处
期刊:Anti-cancer Agents in Medicinal Chemistry
[Bentham Science]
日期:2024-07-18
卷期号:24 (16): 1182-1196
标识
DOI:10.2174/0118715206322163240710112404
摘要
: Cancer is the second leading cause of death globally. Despite some successes, conventional cancer treatments are insufficient to address the growing problem of drug resistance in tumors and to achieve efficient treatment outcomes. Therefore, there is an urgent need to explore new therapeutic options. Ferroptosis, a type of iron- and reactive oxygen species-dependent regulated cell death, has been closely associated with cancer development and progression. Non-coding RNAs (ncRNAs) are a class of RNAs that do not code for proteins, and studies have demonstrated their involvement in the regulation of ferroptosis in cancer. This review aims to explore the molecular regulatory mechanisms of ncRNAs involved in ferroptosis in cancer and to emphasize the feasibility of ferroptosis and ncRNAs as novel therapeutic strategies for cancer. We conducted a systematic and extensive literature review using PubMed, Google Scholar, Web of Science, and various other sources to identify relevant studies on ferroptosis, ncRNAs, and cancer. A deeper understanding of ferroptosis and ncRNAs could facilitate the development of new cancer treatment strategies.
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