灭菌(经济)
材料科学
再生(生物学)
膜
光热治疗
细菌
膜透性
体内
细胞
微生物学
细胞生物学
纳米技术
化学
生物
生物化学
外汇市场
遗传学
生物技术
货币经济学
经济
外汇
作者
Yixuan Huang,Jialun Li,Zhaohan Yu,Jiyao Li,Kunneng Liang,Yi Deng
标识
DOI:10.1002/adma.202414111
摘要
Abstract Phototherapy, such as photothermal therapy (PTT) and photodynamic therapy (PDT) has been a powerful strategy to combat bacterial infection. However, the compact cell membranes of pathogenic bacteria, especially drug‐resistant bacteria, significantly diminish the efficiency of heat conduction and impede the entrance of reactive oxygen species (ROS) into cells, resulting in unsatisfactory sterilization. Enlightened by the membrane feature of competent bacteria, herein a MXene/CaO 2 bio‐heterojunction (MC bio‐HJ) is elaborated to achieve rapid disinfection and promote infected tissue regeneration through activating competent cell‐like antibacterial tactics. The bio‐HJ first compels pathogenic bacteria to become a competent cell‐like stage through the coordination of Ca 2+ and membrane phospholipid, and potentiates the membrane permeability. Assisted by near infrared (NIR) irradiation, the heat and ROS generated from PTT and PDT of bio‐HJ easily pass through bacterial membrane and drastically perturb bacterial metabolism, leading to rapid disinfection. More importantly, employing two in vivo infected model of mice, it have corroborated that the MC bio‐HJs not only effectively accelerate MRSA‐infected cutaneous regeneration, but also considerably boost osseointegration in an infected bone defect after coating on orthopedic implants. As envisaged, this work demonstrates a novel therapeutic tactic with robust antibacterial effect to remedy infected tissue regeneration through activating competent cell‐like stage.
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