化学
催化作用
烷基化
氮气
脱羧
药物化学
有机化学
光化学
作者
Jia‐Li Sui,Xin‐Qian Liu,Shun‐Dan Li,Peng‐Fei Huang,Biquan Xiong,Jin‐Heng Li
标识
DOI:10.1002/cjoc.202400628
摘要
Comprehensive Summary A visible‐light‐induced decarboxylative radical cascade cyclization reaction between N ‐(2‐cyanoaryl)‐acrylamides and alkyl N ‐(acyloxy)phthalimide (NHPI esters) for the construction of phenanthridine derivatives has been developed. This approach utilizes lithium iodide (LiI) and triphenylphosphine (PPh 3 ) as the redox catalysts and the alkyl radical is produced through the photoactivation of the electron donor‐acceptor (EDA) complex. A series of primary, secondary, and tertiary alkyl‐substituted phenanthridines are prepared in up to 82% yield without transition‐metal catalysts, chemical oxidants, or metal‐/organic dye‐based photocatalysts.
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