化学
细胞内
自噬
铁蛋白
铁质
辅活化剂
程序性细胞死亡
细胞生物学
生物化学
细胞凋亡
生物
基因
转录因子
有机化学
作者
Jianai Ji,Yuhui Jin,Sinan Ma,Yuxuan Zhu,Xinyu Bi,Qidong You,Zhengyu Jiang
标识
DOI:10.1021/acs.jmedchem.4c00403
摘要
Ferroptosis, a distinctive form of programmed cell death, has been implicated in numerous pathological conditions, and its inhibition is considered a promising therapeutic strategy. Currently, there is a scarcity of efficient antagonists for directly regulating intracellular ferrous iron. Ferritinophagy, an essential process for supplying intracellular labile iron, relies on nuclear receptor coactivator 4 (NCOA4), a selective autophagy receptor for the ferritin iron storage complex, thus playing a pivotal role in ferritinophagy. In this study, we reported a novel von Hippel-Lindau-based NCOA4 degrader,
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