可穿戴计算机
可穿戴技术
对偶(语法数字)
医学
光电子学
材料科学
纳米技术
计算机科学
嵌入式系统
艺术
文学类
作者
Ming Li,Chenxi Wang,Qiang Yu,Haoyi Chen,Yingying Ma,Li Wei,Mei X. Wu,Min Yao,Min Lu
标识
DOI:10.1038/s41467-024-53579-6
摘要
Phototherapy can offer a safe and non-invasive solution against infections, while promoting wound healing. Conventional phototherapeutic devices are bulky and limited to hospital use. To overcome these challenges, we developed a wearable, flexible red and blue LED (r&bLED) patch controlled by a mobile-connected system, enabling safe self-application at home. The patch exhibits excellent skin compatibility, flexibility, and comfort, with high safety under system supervision. Additionally, we synthesized a sprayable fibrin gel (F-gel) containing blue light-sensitive thymoquinone and red light-synergistic NADH. Combined with bLED, thymoquinone eradicated microbes and biofilms within minutes, regardless of antibiotic resistance. Furthermore, NADH and rLED synergistically improved macrophage and endothelial cell mitochondrial function, promoting wound healing, reducing inflammation, and enhancing angiogenesis, as validated in infected diabetic wounds in mice and minipigs. This innovative technology holds great promise for revolutionizing at-home phototherapy for chronic infected wounds. Chronic wounds significantly diminish quality of life. Here, the authors developed a wearable LED device and sprayable fibrin gel for safe home use. The LED device and fibrin gel effectively eradicated microbes and improved wound healing, as validated in infected diabetic wounds in mice and minipigs
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