医学
睾酮(贴片)
内科学
炎症性肠病
单变量分析
前瞻性队列研究
人口
性激素结合球蛋白
内分泌学
溃疡性结肠炎
钙蛋白酶
胃肠病学
疾病
多元分析
雄激素
激素
环境卫生
作者
Ciaran Judge,Daniel Lightowler,Abhey Singh,Bu B. Yeap,Lena Thin
出处
期刊:Inflammatory Bowel Diseases
[Oxford University Press]
日期:2024-08-07
摘要
Abstract Background An inverse relationship exists between inflammation and testosterone concentrations in non–inflammatory bowel disease (IBD) immune conditions but has not been objectively explored in the IBD male population. We aimed to characterize the distribution of testosterone concentrations in a cohort of males with IBD and identify any relationship between testosterone levels and disease activity. Methods We conducted a prospective cross-sectional study of male IBD patients. Demographics, disease characteristics, sex-hormone concentration, gonadotropins, C-reactive protein, fecal calprotectin, and patient-reported outcomes on quality of life and erectile function were collected. Relationships between disease activity, biomarkers, patient-reported outcome scores, and testosterone levels were analyzed using univariate and multivariate linear regression analyses. Results A total of 85 male IBD patients were included with a mean age 44 ± 14.1 years, of which 49.4% had Crohn’s disease. Mean testosterone concentration was 15.4 ± 5.2 nmol/L and 17.6% had a serum testosterone <10.4 nmol/L. Active disease was associated with lower testosterone concentrations in univariate analysis (β ± SE = −0.25 ± -1.99, P = .02) but not in multivariate analysis (β −0.18 ± 1.75, P = .06). Testosterone concentrations were independently associated with sex hormone–binding globulin levels (β ± SE = 0.45 ± 0.04, P < .0001) and a younger age (β ± SE = −0.32 ± 0.04, P <.0001). Erectile function scores (5-item International Index of Erectile Function) were lower in IBD patients with a longer duration of disease (β ± SE = −0.24 ± 0.006, P = .04). Conclusions Lower testosterone concentrations in men with IBD may reflect confounding from other factors and are not independently associated with disease activity. Greater awareness and screening for sexual dysfunction should occur in males with IBD, particularly in those with a longer disease duration.
科研通智能强力驱动
Strongly Powered by AbleSci AI