化学
废止
原位
氢化物
镍
区域选择性
组合化学
药物化学
有机化学
催化作用
金属
作者
Xu Zhang,Mengfan Chang,Tongtong Ni,Xuhan Zhang,Qiang Zhao,Wenguang Li,Ting Li
出处
期刊:Organic Letters
[American Chemical Society]
日期:2024-07-29
卷期号:26 (31): 6619-6624
标识
DOI:10.1021/acs.orglett.4c02272
摘要
A practical and effective nickel-catalyzed dehydrogenative [4 + 2] annulation of 1-indanones with alkynes was reported. In this protocol, nickel-catalyzed desaturation of 1-indanones and nickel hydride catalyzed coupling with alkynes were first incorporated. A cyclopentadiene-type nickel hydride species was generated in situ via β-H elimination, and they subsequently reacted with a wide variety of alkynes to afford various benzo[a]fluorenone derivatives in good yields and regioselectivity.
科研通智能强力驱动
Strongly Powered by AbleSci AI