重编程
肿瘤微环境
封锁
免疫系统
效应器
癌症研究
免疫检查点
胰腺癌
癌症
免疫疗法
T细胞
医学
生物信息学
生物
免疫学
细胞
受体
内科学
遗传学
作者
Saumya Maru,Elizabeth M. Jaffee
标识
DOI:10.1136/jitc-2024-010124
摘要
Pancreatic adenocarcinoma (PDAC) is considered an immunologically ‘cold’ tumor that fails to attract or support effector T cells. Most PDACs are resistant to immune checkpoint blockade due to the complex signaling pathways that exist within its tumor microenvironment. Recent advances in genomic and proteomic technology advances are finally uncovering the complex inflammatory cellular and intercellular signals that require modulation and reprogramming. The goal is to ‘turn up the heat’ on PDACs with combination immunotherapies that incorporate T cell activating agents and immune modulatory agents, and successfully eradicate tumors. Here, we discuss progress and promising new research that is moving the field toward this goal.
科研通智能强力驱动
Strongly Powered by AbleSci AI