肺癌
串扰
转移
小RNA
癌症研究
相扑蛋白
表观遗传学
乙酰化
机制(生物学)
泛素
医学
生物
生物信息学
癌症
计算生物学
肿瘤科
基因
内科学
遗传学
哲学
物理
认识论
光学
作者
Pooja Gulhane,Shailza Singh
标识
DOI:10.1016/j.tranon.2023.101673
摘要
Non-Small Cell Lung Cancer (NSCLC) is the most prevalent kind of lung cancer with around 85% of total lung cancer cases. Despite vast therapies being available, the survival rate is low (5 year survival rate is 15%) making it essential to comprehend the mechanism for NSCLC cell survival and progression. The plethora of evidences suggests that the Post Translational Modification (PTM) such as phosphorylation, methylation, acetylation, glycosylation, ubiquitination and SUMOylation are involved in various types of cancer progression and metastasis including NSCLC. Indeed, an in-depth understanding of PTM associated with NSCLC biology will provide novel therapeutic targets and insight into the current sophisticated therapeutic paradigm. Herein, we reviewed the key PTMs, epigenetic modulation, PTMs crosstalk along with proteogenomics to analyze PTMs in NSCLC and also, highlighted how epi‑miRNA, miRNA and PTM inhibitors are key modulators and serve as promising therapeutics.
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