流涎
流口水
医学
帕金森病
脑深部刺激
丘脑底核
评定量表
前瞻性队列研究
内科学
麻醉
外科
疾病
心理学
发展心理学
作者
Jinxing Sun,Cheng Lian,Zhenke Li,Jiezhi Jia,Qianqian Wu,Ying Hou,Qi Wang,Guangjian Zhang,Hong Wang,Xingang Li,Weiguo Li,Chao Zhang
标识
DOI:10.1016/j.parkreldis.2024.106075
摘要
Sialorrhea is a common neurological manifestation of Parkinson's disease (PD). No specifically designed prospective study has tested the effects of deep brain stimulation of the subthalamic nucleus (STN-DBS) on sialorrhea in patients with advanced PD. We focused on the effect of STN-DBS on the incidence of sialorrhea in patients with PD.This multicenter, prospective, non-randomized concurrent clinical trial analyzed the incidence of sialorrhea during long-term follow-up in 170 patients with advanced PD (84 patients with STN-DBS and 86 patients with medication therapy).After STN-DBS, 58.1% of patients presented with sialorrhea (Drooling Rating Scale (DRS) > 5) compared with 39.3% of patients with medication therapy (P < 0.001). STN-DBS stimulation demonstrated a significant increase in DRS and Drooling Severity and Frequency Scale (DSFS) compared with the patients with medication therapy (P < 0.001). At follow-up, the onabotulinumtoxin-A (BTX-A) injection ratio was significantly higher in the STN-DBS group (29.8% vs. 11.9%, P = 0.0057) compared with the patients with medication therapy.STN-DBS increased the risk of sialorrhea in patients with advanced PD.clinicaltrials. gov (NCT06090929).
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