达托霉素
医学
利奈唑啉
菌血症
屎肠球菌
内科学
回顾性队列研究
相伴的
肠球菌
万古霉素
耐万古霉素肠球菌
死亡率
外科
抗生素
金黄色葡萄球菌
微生物学
生物
细菌
遗传学
作者
Jung-Jr Ye,Shian‐Sen Shie,Chun-Wen Cheng,Jeng‐How Yang,Po‐Yen Huang,Ting‐Shu Wu,Ming‐Hsun Lee,Ching‐Tai Huang
标识
DOI:10.1016/j.jmii.2017.08.025
摘要
Vancomycin-resistant Enterococcus faecium (VRE-fm) bacteremia causes significant mortality in hospitalized patients. We sought to investigate clinical characteristics, treatment outcomes, and microbiological eradication associated with VRE-fm bacteremia.A retrospective cohort study was conducted and included 210 adult patients admitted between January 1, 2011 and December 31, 2015.The mean Pitt bacteremia score was 4.7. ICU stay (48.6%) and mechanical ventilation (46.2%) were common. Diabetes mellitus was the most common concomitant disease (43.3%), followed by malignancies, including hematologic malignancies (14.3%) and solid cancers (28.1%). The 14-day and 28-day mortality rates were 37.1% and 50.5%, respectively. Linezolid or daptomycin treatment for at least 10 days and higher Pitt bacteremia scores were independently associated with 14-day and 28-day mortality. Longer treatment duration of linezolid or daptomycin predicted microbiological eradication independently. Daptomycin-treated patients tended to have higher 14-day and 28-day mortality, and lower microbial eradication rates (20.8% versus 8.7%; 40.6% versus 26.1%; 14.1% versus 26.1%; respectively) than linezolid-treated patients, and cumulative survival rates at 14 and 28 days tended to be lower in patients who received low-dose daptomycin (<10 mg/kg/day) than that in those who received linezolid and high-dose daptomycin (≥10 mg/kg/day); however, the differences were not statistically significant.Higher disease severity and inappropriate treatment were associated with increased mortality and longer treatment duration of linezolid or daptomycin was associated with microbial eradication for the patient with VRE-fm bacteremia.
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