作者
Ahmet Kılıç,M. Emin KARATAS,Levent Beyazsakal,Veysi Okumuş
摘要
• The boronate ester modified Fe 3 O 4 @APTES-B MNPs were prepared. • The spectroscopic properties and characterization were established by different spectral tools. • The target Fe 3 O 4 @APTES-B 1,2 MNPs are in nanosize since crystal sizes are < 100 nm. • The antioxidant, antimicrobial, and DNA binding activities of all compounds were tested. • Some compounds have been shown to have strong DNA binding activity. We have designed two novel magnetite targeting biological agents (Fe 3 O 4 @APTES-B (1,2) ) with a core of Fe 3 O 4 and a shell made of boronate esters (APTES-B) to improve the biological effectiveness of magnetite Fe 3 O 4 nanoparticles (MNPs). Initially, two boronate esters (B 1 ) and (B 2 ) have been prepared by 3,4-dihydroxybenzaldehyde and phenylboronic acid and/or butylboronic acid using a Dean-Stark apparatus to remove the water formed during the esterification reactions. Then, the APTES-B 1,2 compounds have been synthesized via boronate esters and APTES in the presence of 1–2 drops of formic acid as catalyst. Finally, magnetite Fe 3 O 4 NPs were added to APTES-B 1,2 compounds to afford boronate ester modified magnetite iron nanoparticles (Fe 3 O 4 @APTES-B 1,2 ) at ambient temperature, respectively. The boronate esters (B 1 ) and (B 2 ) , APTES-B 1,2 compounds, and boronate ester modified magnetite iron nanoparticles (Fe 3 O 4 @APTES-B 1,2 ) were characterized using a combination of NMR ( 1 H, 13 C, and 11 B), FT-IR, UV–Vis, LC-MS/MS, elemental analysis (CHN), XRD, SEM-EDX, EDX mapping, BET, and TG-DTA). Then, the antioxidant, antimicrobial and DNA binding activities of newly synthesized target compounds were tested. These results suggest that all compounds are also one of the propitious drug candidates and are worthy of further investigation.