肠化生
慢性胃炎
免疫组织化学
癌症
幽门螺杆菌
金属硫蛋白
医学
胃炎
病理
化生
癌症研究
内科学
生物
基因
生物化学
作者
Noha Helal,M M Moussa,T Aboushousha,M A Aboul-Ezz,Mai Magdy
出处
期刊:DOAJ: Directory of Open Access Journals - DOAJ
日期:2022-05-01
卷期号:26 (9): 3100-3108
被引量:2
标识
DOI:10.26355/eurrev_202205_28727
摘要
Gastric cancer (GC) is a heterogeneous disease with molecular diversity between and within tumors; therefore, searching for altered genes within this cancer is mandatory to reach the proper individualized targeted therapy. Expressions of Metallothionein (MT) and p21 are not uniform in various types of cancers and their predictive value in GC is controversial. This study aimed to assess the role of MT and p21 in intestinal-type GC and some of its precursor lesions.Immunohistochemical staining for MT and p21 was applied on paraffin blocks belonging to 30 GCs and 51 benign gastric lesions/precancerous lesions [33 chronic gastritis and 18 chronic gastritis with gastric intestinal metaplasia (GIM)]; 27 of them were associated with H. pylori infection.MT expression was dramatically increased while p21 expression was dramatically decreased from chronic gastritis to GIM to GC. In precancerous lesions, H. pylori-positive cases had significantly higher MT expression and lower p21 expression compared to H. pylori-negative cases. In GCs, decreased expression of both MT and p21 was associated with high-grade and advanced-stage cancers.Both MT and p21 may have a role in the development and progression of GC, and both proteins may be useful for selecting targeted therapy for GC patients.
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