Fast imaging-based single particle analysis method for solubility determination

溶解度 消耗品 溶解 化学 粒子(生态学) 粒径 分析化学(期刊) 色谱法 生物系统 材料科学 工艺工程 有机化学 物理化学 工程类 地质学 海洋学 生物
作者
Emma Hokkala,Clare J. Strachan,Mikael Agopov,Kristian Semjonov,Jyrki Heinämäki,Jouko Yliruusi,Sami Svanbäck
出处
期刊:International Journal of Pharmaceutics [Elsevier BV]
卷期号:624: 121976-121976 被引量:1
标识
DOI:10.1016/j.ijpharm.2022.121976
摘要

The solubility and dissolution rates of chemical compounds are crucial properties in several fields of industry and research. However, accurate, rapid and green methods for their measurement, which only consume micrograms of compound, are lacking. Here, the unique approach of non-specific, image-based single particle analysis (SPA) for solubility testing is directly compared to and thus validated on the mid-solubility range with the current gold standard shake-flask method with UV-Vis spectroscopy employed for determining sample concentrations. Five biologically active compounds representing a range of physicochemical properties including pKa and logP were analyzed with both methods. The comparison of SPA and the shake-flask (SF) analysis shows excellent linear correlation (R2 = 0.99). Higher variability of the SPA method is attributed to variability between the properties of individual particles, which cannot be detected with traditional methods. Due to the similar average solubility values compared to those produced with SF, it is concluded that the SPA method has great potential as an analytical tool for small-scale solubility studies. It also has several practical advantages over the current gold standard shake-flask method, such as speed, low consumables consumption, and no requirement for prior knowledge of compound chemistry.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
YamDaamCaa应助N0V1CE采纳,获得50
刚刚
ClaudiaCY发布了新的文献求助10
刚刚
猛犸颠勺完成签到,获得积分10
刚刚
悲凉的强炫完成签到,获得积分10
1秒前
SheepIce完成签到,获得积分10
1秒前
你是谁完成签到,获得积分10
2秒前
墨菲特完成签到,获得积分10
2秒前
2秒前
3秒前
kaka091完成签到,获得积分10
4秒前
4秒前
姆姆完成签到,获得积分10
4秒前
5秒前
sunglow11完成签到,获得积分0
6秒前
6秒前
wang完成签到,获得积分10
7秒前
7秒前
李李完成签到 ,获得积分10
7秒前
reirei应助ClaudiaCY采纳,获得10
8秒前
zhuo发布了新的文献求助10
8秒前
冰淇琳发布了新的文献求助10
8秒前
xkyasc完成签到,获得积分10
9秒前
天天快乐应助yuko采纳,获得10
9秒前
量子星尘发布了新的文献求助10
9秒前
10秒前
迷路的夏之完成签到,获得积分10
10秒前
生动之云发布了新的文献求助10
11秒前
瓜子发布了新的文献求助20
11秒前
cczltdy发布了新的文献求助10
11秒前
QUA应助科研通管家采纳,获得10
12秒前
CHENG_2025应助科研通管家采纳,获得20
12秒前
12秒前
乐观小之应助科研通管家采纳,获得10
12秒前
13秒前
科研通AI2S应助科研通管家采纳,获得10
13秒前
13秒前
深情安青应助科研通管家采纳,获得10
13秒前
13秒前
13秒前
沐青应助科研通管家采纳,获得30
13秒前
高分求助中
A new approach to the extrapolation of accelerated life test data 1000
Cognitive Neuroscience: The Biology of the Mind 1000
Technical Brochure TB 814: LPIT applications in HV gas insulated switchgear 1000
Toward a Combinatorial Approach for the Prediction of IgG Half-Life and Clearance 500
ACSM’s Guidelines for Exercise Testing and Prescription, 12th edition 500
Picture Books with Same-sex Parented Families: Unintentional Censorship 500
Nucleophilic substitution in azasydnone-modified dinitroanisoles 500
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 3969917
求助须知:如何正确求助?哪些是违规求助? 3514626
关于积分的说明 11175060
捐赠科研通 3249928
什么是DOI,文献DOI怎么找? 1795165
邀请新用户注册赠送积分活动 875617
科研通“疑难数据库(出版商)”最低求助积分说明 804891