Palladium and Amino Acid Co-Catalyzed Highly Regio- and Enantioselective Hydroarylation of Unbiased Alkenes

A practical palladium and amino acid co-catalyzed hydroarylation of unbiased alkenes has been developed. Using the transient-directing strategy, this chemistry could construct isolated chiral Csp2–Csp3 bonds with good regio- and enantioselectivity. The potential synthetic utility of a representative product was well-illustrated by further transformations. Furthermore, the mechanism of this reaction was intensively studied through control experiments and DFT calculations.