血清转化
临床试验
人类免疫缺陷病毒(HIV)
医学
艾滋病疫苗
免疫学
艾滋病疫苗
病毒学
重症监护医学
疫苗试验
病理
作者
Waynce C. Koff,Daniel F. Hoth
出处
期刊:Science
[American Association for the Advancement of Science (AAAS)]
日期:1988-07-22
被引量:103
标识
DOI:10.1126/science.3293212
摘要
Recent advances in delineating the molecular biology of human immunodeficiency virus type 1 (HIV-1) have led to innovative approaches to development of a vaccine for acquired immunodeficiency syndrome (AIDS). However, the lack of understanding of mechanisms of protective immunity against HIV-1, the magnitude of genetic variation of the virus, and the lack of effective animal models for HIV-1 infection and AIDS have impeded progress. The testing of AIDS vaccines also presents challenges. These include liability concerns over vaccine-related injuries; identification of suitable populations for phase 3 efficacy studies; balancing the ethical obligation to counsel research subjects to avoid high-risk behavior with the necessity to obtain vaccine efficacy data; and the effect of vaccine-induced seroconversion on the recruiting and welfare of trial volunteers. Several candidate AIDS vaccines are nevertheless currently under development, and some are undergoing phase 1 clinical trials. Rapid progress will depend on continued scientific advancement in conjunction with maximum use of resources, open information and reagent exchange, and a spirit of international collaboration.
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