PTEN公司
PI3K/AKT/mTOR通路
前列腺癌
BETA（编程语言）
癌症研究
化学
计算生物学
癌症
药理学
医学
生物
细胞凋亡
内科学
生物化学
计算机科学
程序设计语言
作者
Hong Lin,Mark J. Schulz,Ren Xie,Jin Zhang,Juan I. Luengo,Michael D. Squire,Rosanna Tedesco,Junya Qu,Karl F. Erhard,James F. Mack,Kaushik Raha,Ramona Plant,Cynthia M. Rominger,Jennifer L. Ariazi,Christian Sherk,Michael D. Schaber,Jeanelle McSurdy-Freed,Michael D. Spengler,Charles B. Davis,Mary Ann Hardwicke,Ralph A. Rivero
摘要
A novel thiazolopyrimidinone series of PI3K-beta selective inhibitors has been identified. This chemotype has provided an excellent tool compound, 18, that showed potent growth inhibition in the PTEN-deficient breast cancer cell line MDA-MB-468 under anchorage-independent conditions, and it also demonstrated pharmacodynamic effects and efficacy in a PTEN-deficient prostate cancer PC-3 xenograft mouse model.
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