PTEN公司
PI3K/AKT/mTOR通路
前列腺癌
BETA（编程语言）
癌症研究
化学
计算生物学
癌症
药理学
医学
生物
细胞凋亡
内科学
生物化学
计算机科学
程序设计语言
作者
Hong Lin,Mark J. Schulz,Ren Xie,Jin Zhang,Juan I. Luengo,Michael D. Squire,Rosanna Tedesco,Junya Qu,Karl F. Erhard,James F. Mack,Kaushik Raha,Ramona Plant,Cynthia M. Rominger,Jennifer L. Ariazi,Christian Sherk,Michael D. Schaber,Jeanelle McSurdy-Freed,Michael D. Spengler,Charles B. Davis,Mary Ann Hardwicke,Ralph A. Rivero
摘要
A novel thiazolopyrimidinone series of PI3K-beta selective inhibitors has been identified. This chemotype has provided an excellent tool compound, 18, that showed potent growth inhibition in the PTEN-deficient breast cancer cell line MDA-MB-468 under anchorage-independent conditions, and it also demonstrated pharmacodynamic effects and efficacy in a PTEN-deficient prostate cancer PC-3 xenograft mouse model.
科研通智能强力驱动
Strongly Powered by AbleSci AI
PDF的下载单位、IP信息已删除
SYLH
yar
pcr163
Rondab
916
YamDaamCaa
Bio
风清扬
昏睡的蟠桃
猪猪hero
pluto
CAOHOU
从容芮
热心市民小红花
shinysparrow
CyrusSo524
dong
研友_Y59785
孙孙
挖掘机
皖公网安备34019202002308
