ABCG1公司
ABCA1
流出
胆固醇
胆固醇逆向转运
运输机
平衡
生物
脂质代谢
化学
生物化学
细胞生物学
脂蛋白
基因
作者
Matthew A. Kennedy,Gabriel Barrera,Kotoka Nakamura,Ángel Baldán,Paul T. Tarr,Michael C. Fishbein,Joy S. Frank,Omar L. Francone,Peter A. Edwards
标识
DOI:10.1016/j.cmet.2005.01.002
摘要
Here we demonstrate that the ABC transporter ABCG1 plays a critical role in lipid homeostasis by controlling both tissue lipid levels and the efflux of cellular cholesterol to HDL. Targeted disruption of Abcg1 in mice has no effect on plasma lipids but results in massive accumulation of both neutral lipids and phospholipids in hepatocytes and in macrophages within multiple tissues following administration of a high-fat and -cholesterol diet. In contrast, overexpression of human ABCG1 protects murine tissues from dietary fat-induced lipid accumulation. Finally, we show that cholesterol efflux to HDL specifically requires ABCG1, whereas efflux to apoA1 requires ABCA1. These studies identify Abcg1 as a key gene involved in both cholesterol efflux to HDL and in tissue lipid homeostasis.
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