生物
病毒进入
异种移植
病毒进化
适应(眼睛)
病毒
基因组
病毒学
基因
病毒病机
受体
移植
遗传学
病毒复制
进化生物学
计算生物学
神经科学
外科
医学
作者
Éric Baranowski,Carmen M. Ruiz-Jarabo,Esteban Domingo
出处
期刊:Science
[American Association for the Advancement of Science (AAAS)]
日期:2001-05-11
卷期号:292 (5519): 1102-1105
被引量:266
标识
DOI:10.1126/science.1058613
摘要
Evolution of receptor specificity by viruses has several implications for viral pathogenesis, host range, virus-mediated gene targeting, and viral adaptation after organ transplantation and xenotransplantation, as well as for the emergence of viral diseases. Recent evidence suggests that minimal changes in viral genomes may trigger a shift in receptor usage for virus entry, even into the same cell type. A capacity to exploit alternative entry pathways may reflect the ancient evolutionary origins of viruses and a possible role as agents of horizontal gene transfers among cells.
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