蛋白质酪氨酸磷酸酶
B细胞受体
细胞生物学
断点群集区域
生物
B细胞
抗原
免疫系统
受体
免疫受体酪氨酸激活基序
平衡
自身免疫
信号转导
免疫学
抗体
生物化学
SH2域
作者
Atsushi Kumanogoh,Takashi Shikina,Chie Watanabe,Noriko Takegahara,Kazuhiro Suzuki,Midori Yamamoto,Hyota Takamatsu,Durbaka V. R. Prasad,Masayuki Mizui,Toshihiko Toyofuku,Manabu Tamura,Dai Watanabe,Jane R. Parnes,Hitoshi Kikutani
标识
DOI:10.1093/intimm/dxh307
摘要
Co-receptors on the B-cell surface regulate B-cell antigen receptor (BCR) signaling; however, it remains unclear how BCR signals are coordinated to maintain immune homeostasis. CD72, a negative regulator of B-cell responses, has immunoreceptor tyrosine-based inhibitory motifs within its cytoplasmic region, and the tyrosine phosphatase SHP-1 binds these sites. The natural ligand of CD72, CD100/Sema4D, belongs to the semaphorin family and induces the dissociation of SHP-1 from CD72, thereby switching off the negative signals of CD72. In the absence of CD100, BCR signals are significantly suppressed due to the constitutive association of SHP-1 with CD72, resulting in B-cell hyporesponsiveness. Here we show that CD100 regulates the sensitivity of the BCR by preventing the association of the CD72 with BCR, and this interaction is required for proper B-cell homeostasis. Consequently, as CD100-deficient mice age, they accumulate marginal zone B cells and develop high auto-antibody levels and autoimmunity. Collectively, our findings indicate that the strength of BCR signals is strictly tuned by the interaction of CD100 with CD72, and this interaction is essential for maintaining immunological homeostasis as well as generating a proper immune response.
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