药物遗传学
医学
阿司匹林
结直肠癌
环氧合酶
癌症
药理学
乳腺癌
生物信息学
内科学
生物
酶
基因
生物化学
基因型
作者
Cornelia M. Ulrich,Jeannette Bigler,John D. Potter
出处
期刊:Nature Reviews Cancer
[Springer Nature]
日期:2006-02-01
卷期号:6 (2): 130-140
被引量:487
摘要
Aspirin and other non-steroidal anti-inflammatory drugs (NSAIDs) show indisputable promise as chemopreventive agents. Possible targets include cancers of the colon, stomach, breast and lung. However, recent studies raise concern about potential cardiovascular toxicity associated with the use of NSAIDs that specifically target the enzyme cyclooxygenase 2. These findings, and others that show that inherited genetic characteristics might determine preventive success, argue for new strategies that are tailored to individual medical history and genetic make-up.
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