化学
脚手架
荧光
红外线的
合理设计
组合化学
纳米技术
生物医学工程
光学
医学
物理
材料科学
作者
Tongliang Zhou,Lingfei Yang,Lei Liang,Hui Liu,Yinye Wang,Mengyang Shui,Lan Yuan,Fengrong Xu,Yan Niu,Chao Wang,Ping Xu
标识
DOI:10.1002/ejoc.201700355
摘要
A class of pyridazinone derivatives as near-infrared optical probes in fluorescence microscopy images was designed. The design strategy consisted of the stepwise extension and modification of pyridazinone by expansion of the electron-donating moiety to a larger π-conjugated system and anchoring a subcellular directing group such as triphenylphosphine or morpholine. All the desired products were successfully applied in cell imaging with high subcellular colocalization. Furthermore, these fluorescent probes showed excellent performance in mouse-brain imaging.
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