The Highly Efficient Beckmann Rearrangement of Ketoximes to Amides By Using Mukaiyama Reagent Under Mild Conditions

Background: A rapid and efficient synthesis of amides via Beckmann rearrangement of ketoximes with good to excellent yields has been carried out using Mukaiyama reagent/Et3N system. The procedure is mild and suitable for both aromatic and cycloaliphatic substrates affording the products in good to quantitative yields with short reaction times. Keywords: Amide, beckmann rearrangement, ketoxime, mukaiyama reagent.