脂肪性肝炎
脂肪肝
医学
脂肪变性
胰岛素抵抗
内分泌学
内科学
转录组
生物
疾病
癌症研究
胰岛素
生物化学
基因
基因表达
作者
Amon Asgharpour,Sophie C. Cazanave,Tommy Pacana,Mulugeta Seneshaw,Robert Vincent,Bubu A. Banini,Divya P. Kumar,Kalyani Daita,Hae-Ki Min,Faridoddin Mirshahi,Pierre Bédossa,Xiaochen Sun,Yujin Hoshida,Srinivas V. Koduru,Daniel Contaifer,Urszula Osinska Warncke,Dayanjan S. Wijesinghe,Arun J. Sanyal
标识
DOI：10.1016/j.jhep.2016.05.005
摘要
We have developed a diet-induced mouse model of non-alcoholic steatohepatitis (NASH) and hepatic cancers in a cross between two mouse strains (129S1/SvImJ and C57Bl/6J). This model mimics all the physiological, metabolic, histological, transcriptomic gene signature and clinical endpoints of human NASH and can facilitate preclinical development of therapeutic targets for NASH.
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(2025-6-4)
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