临床试验
考试(生物学)
范畴变量
协议(科学)
萧条(经济学)
金标准(测试)
医学
抗抑郁药
心理学
精神科
临床心理学
内科学
替代医学
机器学习
计算机科学
病理
焦虑
宏观经济学
古生物学
经济
生物
作者
Miguel Farinha‐Ferreira,Lígia Neves Castanheira,Ana M. Sebastião,Diogo Telles‐Correia
标识
DOI:10.2174/1568026618666181115095920
摘要
Depression is deeply rooted in human behavior. The development of new antidepressants demands the creation of animal models to investigate new drugs, which potentially could work as antidepressants. The aim of this review is to discuss the different ways of assessing depression in clinical research, including clinical trials, and the different animal behavioral tests used to study depression and test the efficacy of antidepressants in pre-clinical studies. In clinical practice, a categorical classification, such as the Diagnostic and Statistical Manual of Mental Disorders (DSM) and the International Statistical Classification of Diseases and Related Health Problems (ICD) can be used for diagnosis, through the use of structured and semi-structured interviews. On the other hand, depression can also be assessed using a dimensional approach, through self- or clinicianrated questionnaires. Regarding the assessment of the efficacy of antidepressants in animal models, several tests are routinely used, namely the Forced Swim Test, the Modified Forced Swim Test, the Tail Suspension Test and the Sucrose Preference Test. These tests are informative, providing that the following rules are taken into account: 1) more than one test is used, with coherent results; 2) secondary drug effects, the most frequent being putative changes in motor activity, are taken into account and properly controlled with specific tests run concomitantly; 3) each test and specific protocol is validated with data from at least a gold standard antidepressant drug. We herein briefly discuss the potential and limitations of each of those tests.
科研通智能强力驱动
Strongly Powered by AbleSci AI