Cortico-spinal tDCS in ALS: A randomized, double-blind, sham-controlled trial

Amyotrophic lateral sclerosis (ALS) is a progressive disease which affects both upper and lower motor neurons, with a fatal prognosis, for which no curative treatment is currently available. Glutamate-driven excitotoxicity is supposed to be involved in its pathophysiology, and drugs such as riluzole or edaravone have shown to reduce disease progression in ALS to a limited extent.