医学
人口
库欣病
流行病学
内分泌系统
腺瘤
入射(几何)
病因学
垂体腺瘤
肾上腺腺瘤
疾病
内科学
库欣综合征
内分泌疾病
内分泌学
儿科
激素
物理
光学
环境卫生
作者
Osamah A Hakami,Shahzada Ahmed,Niki Karavitaki
标识
DOI:10.1016/j.beem.2021.101521
摘要
Endogenous Cushing’s syndrome (CS) is a rare endocrine disorder characterised by excess cortisol secretion due to either ACTH-dependent conditions [commonly an ACTH-producing pituitary adenoma (Cushing’s disease)] or ACTH-independent causes (with most common aetiology being a benign adrenal adenoma). Overall, the annual incidence of CS ranges between 1.8 and 3.2 cases per million population. Mortality in active CS is elevated compared to the general population, and a number of studies support the view that survival is also compromised even after apparent successful treatment. The main cause of death is cardiovascular disease highlighting the negative impact of cortisol excess on cardiovascular risk factors. Early diagnosis and prompt treatment of the cortisol excess, as well as vigilant monitoring and stringent control of cardiovascular risk factors are key elements for the long-term prognosis of these patients.
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