Liver and Brain Protective Effect of Sulfated Polysaccharides from Residue of Lion's Mane Medicinal Mushroom, Hericium erinaceus (Agaricomycetes), on D-Galactose-Induced Aging Mice

This work describes the preparation of sulfated Hericium erinaceus residue polysaccharides (SHRPs) and investigates their antioxidant and antiaging effects on D-galactose-induced aging mice. The results indicated that the degree of SO42- substitution was 0.47 ± 0.22 for SHRPs. In vitro analysis and in vivo animal experiments manifested that SHRPs could alleviate aging properties by scavenging radicals, elevating enzyme activities, and reducing malondialde-hyde content, thus improving serum biochemical indices and enhancing immunological activity. Liver and brain injuries of mice could be remitted by SHRP interventions. Structural characteristics of SHRPs in this work were elucidated by Fourier transform infrared spectroscopy and gas chromatography-mass spectrometry, and the results suggest that SHRPs could be used as an effective dietary supplement and functional food for prevention of aging and age-related diseases.