Resistance-related protein in rectal cancer tissue expression and significance of combination chemotherapy with Ligustrazine

Objective To investigate resistance-related protein in tumor tissue expression and significance of combination chemotherapy with Ligustrazine.Methods In this paper,drug-resistant cancer patients resected tumor tissue was isolated preparation of cell suspension.Study of P-170,MRP and LRP by using flow cytometry and Western-Blotting to elucidate the mechanism of drug resistance,and use traditional Chinese medicine Ligustrazine reversal of multidrug resistance experiments.Results LOVO/5-FU resistance in the mechanism of drug-resistant mainly by increasing P-170,MRP protein expression.Chinese medicine Ligustrazine can be adopted to reduce P-170,MRP protein expression to sensitize drug resistant rectal cancer cells.Conclusions Ligustrazine can increase the resistance of cancer cells to chemotherapeutic drug sensitivity,then the Ligustrazine can effectively increase the ORR in patients with short-term effect,worthy to be popularized.