医学
睑板腺
痤疮丙酸杆菌
结膜
角膜结膜炎
皮肤病科
角膜炎
眼睑
春季角膜结膜炎
角膜
沙拉嗪(真菌)
病理
免疫学
眼科
痤疮
出处
期刊:Cornea
[Ovid Technologies (Wolters Kluwer)]
日期:2012-10-03
卷期号:31 (Supplement 1): S41-S44
被引量:49
标识
DOI:10.1097/ico.0b013e31826a04dd
摘要
Meibomian gland inflammation, "meibomitis," is associated with ocular surface inflammatory diseases. However, these diseases are poorly defined clinically, making effective treatment difficult. Herein, we propose a new disease subset, termed meibomitis-related keratoconjunctivitis (MRKC). The ocular surface features of MRKC include: meibomitis with redness and swelling of the eyelid margin and palpebral conjunctiva; superficial vascularization and granulomatous nodules in the cornea; and conjunctival hyperemia, similar or identical to that observed in phlyctenular keratitis. The characteristics of MRKC patients include a significantly higher prevalence in women, multiple history of chalazia, close association with meibomitis, the presence of specific human leukocyte antigen association, high Propionibacterium acnes detection rates in meibum culture, and the effectiveness of systemic antimicrobial therapy targeting P. acnes. MRKC may share many clinical features with ocular rosacea, especially during childhood. The clinical effectiveness of systemic antimicrobial agents in treating both diseases suggests the importance of focusing on the elimination of bacteria such as P. acnes.
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