乳糜微粒
脂蛋白脂酶
极低密度脂蛋白
肝脂肪酶
脂蛋白
脂肪酶
低密度脂蛋白受体相关蛋白8
脂质代谢
生物
中密度脂蛋白
生物化学
化学
细胞生物学
酶
胆固醇
作者
Shuangcheng Wu,Sander Kersten,Ling Qi
标识
DOI:10.1016/j.tem.2020.11.005
摘要
Lipoprotein lipase (LPL) is one of the most important factors in systemic lipid partitioning and metabolism. It mediates intravascular hydrolysis of triglycerides packed in lipoproteins such as chylomicrons and very-low-density lipoprotein (VLDL). Since its initial discovery in the 1940s, its biology and pathophysiological significance have been well characterized. Nonetheless, several studies in the past decade, with recent delineation of LPL crystal structure and the discovery of several new regulators such as angiopoietin-like proteins (ANGPTLs), glycosylphosphatidylinositol-anchored high-density lipoprotein-binding protein 1 (GPIHBP1), lipase maturation factor 1 (LMF1) and Sel-1 suppressor of Lin-12-like 1 (SEL1L), have completely transformed our understanding of LPL biology.
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