废止
艾伦
化学
磷化氢
芳基
立体选择性
催化作用
酮
甲基酮
有机化学
药物化学
组合化学
烷基
作者
Zifeng Qin,Rongfang Liu,Rong Zhou,Ruifeng Li,Zhengjie He
标识
DOI:10.1002/ajoc.201900635
摘要
Abstract Phosphine‐catalyzed [3+2] and [2+4] annulation reactions of γ‐methyl allenoates with aryl α‐keto esters are described. Under the catalysis of triarylphosphine, γ‐methyl allenoates participate in both the [3+2] annulation with aroylformates and [2+4] annulation with ortho ‐hydroxy aroylformates smoothly to bring about functionalized tetrahydrofurans and 4‐chromanols, respectively, in moderate to excellent yields with high stereoselectivity. The reactions herein also represent rare successful examples of phosphine‐catalyzed allene−ketone transformations, and further expand the scope of ketones in allene chemistry under phosphine catalysis.
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