免疫组织化学
膀胱癌
信使核糖核酸
医学
病理
临床意义
淋巴结
阶段(地层学)
癌症
内科学
肿瘤科
癌症研究
生物
基因
生物化学
古生物学
作者
Samia Hussein,Anan Fathi,Nehal S. Abouhashem,Samar A. Amer,Mohamed Hemeda,Hala Mosaad
出处
期刊:Cancer Biomarkers
[IOS Press]
日期:2021-02-22
卷期号:30 (2): 249-259
被引量:8
摘要
Studying bladder cancer molecular biology revealed the presence of genetic alterations. So, detection of molecular biomarkers that help in monitoring the disease, evaluating the prognosis of the patients, and their response to therapy is needed. In this study, we investigated the expression and the prognostic significance of SATB-1 and ERBB2 mRNA and protein by quantitative RT-PCR and immunohistochemical analysis in urothelial bladder cancer cases and the surrounding normal bladder tissue. The correlations between the expression of both markers and the clinicopathological parameters were performed with further analysis of the correlation between the expression of SATB-1 and ERBB2. Compared to control, the expression of SATB-1 and ERBB2 mRNA and protein in cancer tissues were significantly up-regulated (p< 0.05). Also, a positive correlation between both markers was found (r= 0.53, p< 0.001). Moreover, elevated levels of both markers were significantly associated with the stage, lymph node involvement at both mRNA and protein levels (p< 0.001). In conclusion, there is a clinical significance of SATB-1 and ERBB2 as potential biomarkers for predicting bladder cancer patients of aggressive behavior and poor prognosis.
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