[Surgical and comprehensive treatment for intrahepatic cholangiocarcinoma patients from the perspective of tumor heterogeneity].

Intrahepatic cholangiocarcinoma(ICC) is generally found late along with extremely poor prognosis and lack of effective and standardized treatment. Tremendous heterogeneities exist in onset factors, geographic distribution, clinical manifestation, and biological characteristics of ICC patients. However, the relevant causes and mechanisms have not been clearly illustrated. Recent studies indicate that the diverse celluar origins of ICC, including liver cells, bile duct epithelial cells, glandular cells around the duct, and liver stem cells, etc. Besides, the tumorigenesis, progression and metastasis of ICC are closed related to metabolism such as glucose, lipid metabolism. It can be inferred that the varieties of biological characteristics and clinical manifestation of ICC patients are possibly closely linked with heterogeneous cellular origins, multiple metabolic mechanisms or pathways. Therefore, it's necessary to conduct research with regard to the connection between cellular origins, cell metabolism and clinical manifestation, biological characteristics, and make further classifications. Based on the accurate classification, surgeons can exert corresponding surgical and comprehensive treatment strategies on ICC patients, attaining the goal of individualized and standardized treatment, ultimately, improving prognosis and prolonging survival time.肝内胆管细胞癌(ICC)的发病因素、地域分布、临床表现、生物学特征等存在较大异质性，发病机制尚未明确。近年来的研究发现，ICC的细胞起源呈多元化，包括肝细胞、胆管上皮细胞、管周腺体细胞和肝干细胞等，ICC的发生、发展及转移等与糖代谢、脂代谢等多种代谢密切相关。ICC的生物学特征、临床表现的异质性可能与其多元化细胞起源、多种代谢机制及途径密切相关。因此，需要深入研究ICC的细胞起源和代谢特点与临床特征和生物学特性之间相关性并进行分类。根据分类采取相应的外科及综合治疗策略，做到个体化、规范化的精细治疗，改善患者预后，延长生存时间。.