医学
无症状的
爆发
肺炎
大流行
疾病
冠状病毒
2019年冠状病毒病(COVID-19)
检疫
血清学
病毒性肺炎
过度诊断
重症监护医学
人口统计学的
儿科
免疫学
内科学
传染病(医学专业)
病毒学
抗体
病理
人口学
社会学
作者
Xiang Dong,Yiyuan Cao,Xiaoxia Lü,Jinjin Zhang,Hui Du,Youqin Yan,Cezmi A. Akdiş,Yadong Gao
出处
期刊:Allergy
[Wiley]
日期:2020-03-20
卷期号:75 (7): 1699-1709
被引量:380
摘要
Abstract Background and aims The outbreak of coronavirus disease 2019 (COVID‐19) caused by severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) infection has recently spread worldwide and been declared a pandemic. We aim to describe here the various clinical presentations of this disease by examining eleven cases. Methods Electronic medical records of 11 patients with COVID‐19 were collected, and demographics, clinical manifestations, outcomes, key laboratory results, and radiological images are discussed. Results The clinical course of the eleven cases demonstrated the complexity of the COVID‐19 profile with different clinical presentations. Clinical manifestations range from asymptomatic cases to patients with mild and severe symptoms, with or without pneumonia. Laboratory detection of the viral nucleic acid can yield false‐negative results, and serological testing of virus‐specific IgG and IgM antibodies should be used as an alternative for diagnosis. Patients with common allergic diseases did not develop distinct symptoms and severe courses. Cases with a pre‐existing condition of chronic obstructive pulmonary disease or complicated with a secondary bacterial pneumonia were more severe. Conclusion All different clinical characteristics of COVID‐19 should be taken into consideration to identify patients that need to be in strict quarantine for the efficient containment of the pandemic.
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