亲爱的研友该休息了!由于当前在线用户较少,发布求助请尽量完整的填写文献信息,科研通机器人24小时在线,伴您度过漫漫科研夜!身体可是革命的本钱,早点休息,好梦!

Comparative efficacy of subcutaneous versus oral methotrexate in active rheumatoid arthritis.

医学 类风湿性关节炎 内科学 甲氨蝶呤 恶心 痹症科 不利影响 关节炎 呕吐 皮下注射 胃肠病学 B组
作者
M S Islam,Syed Atiqul Haq,Md Monirul Islam,Abul Kalam Azad,M A Islam,Rajib Barua,Md. Mehedi Hasan,Muhammad Muzaffar Mahmood,Md. Safiuddin,M M Rahman,M F Osmany,N Bari,R S Rumki,Farah Rashid
出处
期刊:PubMed 卷期号:22 (3): 483-8 被引量:11
链接
标识
摘要

This prospective study was conducted in rheumatology clinic under the department of medicine of Bangabandhu Sheikh Mujib Medical University from December 2004 to December 2005 to asses the efficacy, safety and compliance of subcutaneous methotrexate (MTX) in active rheumatoid arthritis (RA) patients. A total of 92 active rheumatoid arthritis patients according to American College of Rheumatology (ACR) criteria were recruited for the trial for six months. Among them 46 cases belonged to injectable MTX group and 46 cases belonged to oral MTX group. Mean±SD age of patients was 45.54±12.42 vs. 44.63±13.99 years in subcutaneous group and oral group respectively. In the subcutaneous group 41 were female and 5 male; in the oral group 34 were female and 12 male. Mean duration of the disease was 49.74 months in subcutaneous group and 49 months in oral group. RA test was positive in 35 cases in both groups whereas Rose Waaler test was positive in 19 patients in subcutaneous group and 14 patients in oral group. At 24 week, response rate of ACR 20 was significantly higher in subcutaneous MTX than oral MTX group (93% vs. 80%, p=0.02). Similarly ACR 50 response was significantly higher in subcutaneous MTX than in oral group (89% vs. 72%, p=0.03). ACR 70 response was not significantly higher in SCMTX group then oral group (11% vs. 9 %, p=0.72). Adverse effects were relatively less in subcutaneous MTX and most common side effects were nausea (37% vs. 63%), vomiting (11% vs. 30%), dyspepsia (29% vs. 48%), dizziness (4l% vs. 52%) and alopecia (72% vs. 85%). The results of the study demonstrated that subcutaneous MTX was significantly more effective than oral MTX at the same dosage in active Rheumatoid arthritis patients with no increase in side effects.

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
大幅提高文件上传限制,最高150M (2024-4-1)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
SciKid524完成签到 ,获得积分10
5秒前
河鲸完成签到 ,获得积分10
11秒前
14秒前
16秒前
花开发布了新的文献求助10
21秒前
爱静静应助科研通管家采纳,获得10
21秒前
21秒前
爱静静应助科研通管家采纳,获得10
21秒前
乐乐应助科研通管家采纳,获得10
21秒前
22秒前
25秒前
huanglu发布了新的文献求助10
28秒前
Yanice_Wan完成签到 ,获得积分10
31秒前
颖中竹子完成签到,获得积分10
35秒前
kongchanjie完成签到,获得积分10
35秒前
迷人的千易完成签到,获得积分10
38秒前
44秒前
45秒前
cc完成签到 ,获得积分10
48秒前
Lucas应助huanglu采纳,获得10
51秒前
CSS发布了新的文献求助10
51秒前
YUAN发布了新的文献求助20
53秒前
如果完成签到 ,获得积分10
1分钟前
1分钟前
漂亮寻云发布了新的文献求助10
1分钟前
闪闪善若完成签到 ,获得积分10
1分钟前
aass发布了新的文献求助10
1分钟前
1分钟前
糖伯虎完成签到 ,获得积分10
1分钟前
诚心的又夏完成签到,获得积分10
1分钟前
vivid完成签到,获得积分10
1分钟前
aass完成签到,获得积分10
1分钟前
1分钟前
xxh完成签到,获得积分10
1分钟前
1分钟前
xxh发布了新的文献求助10
1分钟前
草莓啵啵兔完成签到 ,获得积分10
1分钟前
保持好心情完成签到 ,获得积分10
1分钟前
野生菜狗发布了新的文献求助10
1分钟前
huanglu发布了新的文献求助10
1分钟前
高分求助中
The Young builders of New china : the visit of the delegation of the WFDY to the Chinese People's Republic 1000
юрские динозавры восточного забайкалья 800
English Wealden Fossils 700
麻省总医院内科手册(原著第8版) (美)马克S.萨巴蒂尼 500
Chen Hansheng: China’s Last Romantic Revolutionary 500
宽禁带半导体紫外光电探测器 388
COSMETIC DERMATOLOGY & SKINCARE PRACTICE 388
热门求助领域 (近24小时)
化学 医学 生物 材料科学 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 基因 遗传学 催化作用 物理化学 免疫学 量子力学 细胞生物学
热门帖子
关注 科研通微信公众号,转发送积分 3142628
求助须知:如何正确求助?哪些是违规求助? 2793538
关于积分的说明 7806782
捐赠科研通 2449789
什么是DOI,文献DOI怎么找? 1303425
科研通“疑难数据库(出版商)”最低求助积分说明 626871
版权声明 601314