组蛋白
组蛋白脱乙酰基酶
HDAC6型
HDAC4型
化学
染色质
罗咪酯肽
组蛋白脱乙酰基酶2
组蛋白脱乙酰酶抑制剂
组蛋白乙酰转移酶
曲古抑菌素A
转录因子
作者
Alessia Peserico,Cristiano Simone
摘要
The balance between protein acetylation and deacetylation controls several physiological and pathological cellular processes, and the enzymes involved in the maintenance of this equilibrium—acetyltransferases (HATs) and deacetylases (HDACs)—have been widely studied. Presently, the evidences obtained in this field suggest that the dynamic acetylation equilibrium is mostly maintained through the physical and functional interplay between HAT and HDAC activities. This model overcomes the classical vision in which the epigenetic marks of acetylation have only an activating function whereas deacetylation marks have a repressing activity. Given the existence of several players involved in the preservation of this equilibrium, the identification of these complex networks of interacting proteins will likely foster our understanding of how cells regulate intracellular processes and respond to the extracellular environment and will offer the rationale for new therapeutic approaches based on epigenetic drugs in human diseases.
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