Neutrophil to Lymphocyte Ratio as a Marker in Patients with Non-Arteritic Anterior Ischemic Optic Neuropathy in HRH Princess Maha Chakri Sirindhorn Medical Center

Background: Non anterior ischemic optic neuropathy (NAION) is the most common form of ischemic optic neuropathy. usually associated with systemic vasculopathy disease and has variable visual outcomes. The mechanism of NAION is not fully understood and there is no treatment have been proven to be standard treatment. Objective: To evaluate Neutrophil to Lymphocyte Ratio in Non-arteritic Anterior Ischemic Optic Neuropathy patients in HRH Princess Maha Chakri Sirindhorn Medical Center. Design: Retrospective crossectional study. Materials and Methods: 90 patients in the present study were categorized equally into three groups. Group one was those who were diagnosed with NAION. Group two and three as control groups were those who were diagnosed with cataract with and without systemic diseases respectively. The complete blood count was examined at the first visit of NAION or at the pre-operative day. NLR in each group was calculated and compared. Results: The average of NLR in the group one was 2.25, in the group two and group three were 1.69 and 1.74 respectively. The comparison of mean continuous variable between 3 groups using Oneway ANOVA was analysed. NLR in group one was higher with statistical significance (p<0.05) when compared with group two but there was no statistical significance between group one and group three or group two and group three. The level of NLR has the negative correlation with the improvement of BCVA at 3 months. Conclusion: NLR ratio is one of the marker that can be found elevated when there is an inflammatory reaction, in the present study there is a significant higher of NLR ratio in NAION group and has negative correlation with vision at three months, NLR could be used as a prognostic indicator for the prediction of Visual outcome. Keywords: Non arteritic anterior ischemic optic neuropathy; Neutrophil lymphocyte ratio (NLR); Prognostic indicator; Prediction; Visual outcome