结合
药品
抗体-药物偶联物
抗体
细胞毒性T细胞
药理学
化学
癌症研究
医学
单克隆抗体
免疫学
体外
生物化学
数学
数学分析
作者
Beverly A. Teicher,Joel Morris
出处
期刊:Current Cancer Drug Targets
[Bentham Science]
日期:2022-07-01
卷期号:22 (6): 463-529
被引量:12
标识
DOI:10.2174/1568009622666220224110538
摘要
Abstract: Antibody-drug conjugates offer the possibility of directing powerful cytotoxic agents to a malignant tumor while sparing normal tissue. The challenge is to select an antibody target expressed exclusively or at highly elevated levels on the surface of tumor cells and either not all or at low levels on normal cells. The current review explores 78 targets that have been explored as antibody-drug conjugate targets. Some of these targets have been abandoned, 9 or more are the targets of FDA-approved drugs, and most remain active clinical interest. Antibody-drug conjugates require potent cytotoxic drug payloads, several of these small molecules are discussed, as are the linkers between the protein component and small molecule components of the conjugates. Finally, conclusions regarding the elements for the successful antibody-drug conjugate are discussed.
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