Hybrid liposome/metal–organic framework as a promising dual-responsive nanocarriers for anticancer drug delivery

纳米载体 脂质体 材料科学 抗癌药 药物输送 药品 靶向给药 金属有机骨架 对偶(语法数字) 药理学 化学 纳米技术 医学 有机化学 吸附 艺术 文学类
作者
Abdollah Karami,Ahmed Ahmed,Rana Sabouni,Ghaleb A. Husseini,Miral Al Sharabati,Nour M. AlSawaftah,Vinod Paul
出处
期刊:Colloids and Surfaces B: Biointerfaces [Elsevier]
卷期号:217: 112599-112599 被引量:18
标识
DOI:10.1016/j.colsurfb.2022.112599
摘要

In this work, liposome-coated iron (III) benzene-1,3,5-tricarboxylate (Fe-BTC) metal–organic framework is examined as a promising pH/Ultrasound dual-responsive nanocarriers for doxorubicin (DOX) delivery. The successful coating of the MOF particles (Lip-Fe-BTC) with the phospholipid bilayer (PBL) was established by direct fusion into the synthesized liposomes. The liposome coating was verified using several techniques, including dynamic light scattering (DLS) and transmission electron microscopy (TEM). The DLS measurements showed an increase in the average particle diameter of liposomes from 150 nm to 163.1 nm for Lip-Fe-BTC particles. The Fe-BTC particles had the highest average particle diameter (287.3 nm). These results demonstrated that the PBL reduced the aggregation of the particles and improved their dispersity in the release medium. The TGA results demonstrated the MOF's excellent thermal stability. Furthermore, the nanocarrier's loading efficiency and capacity were determined to be ~90% and ~13.5 wt%, respectively. The in-vitro DOX release experiments demonstrated that the DOX-loaded Fe-BTC and liposome-coated Fe-BTC particles showed good pH and US dual-responsive capability, making them promising nanocarriers for drug delivery. The application of US enhanced DOX release from both Fe-BTC and liposome-coated Fe-BTC. In the case of Fe-BTC-DOX particles, the application of US enhanced the DOX release to around 38% and 67%, at pH levels of 7.4 and 5.3, respectively. Similarly, DOX release from the Lip-Fe-BTC-DOX particles reached ~35% and ~53%, at pH levels of 7.4 and 5.3, respectively. The MTT assay showed the biocompatibility and low cytotoxicity of these nanocarriers below 100 µg/ml.
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