[Construction of a predictive model for early acute kidney injury risk in intensive care unit septic shock patients based on machine learning].

降钙素原 医学 感染性休克 急性肾损伤 重症监护室 接收机工作特性 阿帕奇II 机械通风 重症监护医学 血液滤过 沙发评分 肾脏替代疗法 肌酐 休克(循环) 急诊医学 内科学 败血症 血液透析
作者
Suzhen Zhang,Sujuan Tang,Rong Shan,Manchen Zhu,Jianguo Liu,Qinghe Hu,Cuiping Hao
出处
期刊:PubMed 卷期号:34 (3): 255-259 被引量:3
标识
DOI:10.3760/cma.j.cn121430-20211126-01790
摘要

To analyze the risk factors of acute kidney injury (AKI) in patients with septic shock in intensive care unit (ICU), construct a predictive model, and explore the predictive value of the predictive model.The clinical data of patients with septic shock who were hospitalized in the ICU of the Affiliated Hospital of Jining Medical College from April 2015 to June 2019 were retrospectively analyzed. According to whether the patients had AKI within 7 days of admission to the ICU, they were divided into AKI group and non-AKI group. 70% of the cases were randomly selected as the training set for building the model, and the remaining 30% of the cases were used as the validation set. XGBoost model was used to integrate relevant parameters to predict the risk of AKI in patients with septic shock. The predictive ability was assessed through receiver operator characteristic curve (ROC curve), and was correlated with acute physiology and chronic health evaluation II (APACHE II), sequential organ failure assessment (SOFA), procalcitonin (PCT) and other comparative verification models to verify the predictive value.A total of 303 patients with septic shock were enrolled, including 153 patients with AKI and 150 patients without AKI. The incidence of AKI was 50.50%. Compared with the non-AKI group, the AKI group had higher APACHE II score, SOFA score and blood lactate (Lac), higher dose of norepinephrine (NE), higher proportion of mechanical ventilation, and tachycardiac. In the XGBoost prediction model of AKI risk in septic shock patients, the top 10 features were serum creatinine (SCr) level at ICU admission, NE use, drinking history, albumin, serum sodium, C-reactive protein (CRP), Lac, body mass index (BMI), platelet count (PLT), and blood urea nitrogen (BUN) levels. Area under the ROC curve (AUC) of the XGBoost model for predicting the risk of AKI in patients with septic shock was 0.816, with a sensitivity of 73.3%, a specificity of 71.7%, and an accuracy of 72.5%. Compared with the APACHE II score, SOFA score and PCT, the performance of the model improved significantly. The calibration curve of the model showed that the goodness of fit of the XGBoost model was higher than the other scores (the calibration curve had the lowest score, with a score of 0.205).Compared with the commonly used clinical scores, the XGBoost model can more accurately predict the risk of AKI in patients with septic shock, which helps to make appropriate diagnosis, treatment and follow-up strategies while predicting the prognosis of patients.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
小v完成签到 ,获得积分10
刚刚
Gigi完成签到,获得积分10
1秒前
ssssssssci完成签到,获得积分10
1秒前
Owen应助大气灵枫采纳,获得10
2秒前
独特乘风完成签到,获得积分10
5秒前
含糊的代丝完成签到 ,获得积分10
8秒前
朴素的紫安完成签到 ,获得积分10
9秒前
yyj完成签到,获得积分10
10秒前
11秒前
11秒前
量子星尘发布了新的文献求助10
11秒前
君临完成签到,获得积分10
11秒前
林早上完成签到,获得积分20
11秒前
xiu完成签到 ,获得积分10
12秒前
栗爷完成签到,获得积分0
12秒前
深年完成签到,获得积分10
13秒前
求知若渴完成签到,获得积分0
13秒前
所所应助科研通管家采纳,获得10
13秒前
情怀应助科研通管家采纳,获得10
13秒前
华仔应助科研通管家采纳,获得30
13秒前
李爱国应助科研通管家采纳,获得10
14秒前
Orange应助科研通管家采纳,获得10
14秒前
我是老大应助科研通管家采纳,获得10
14秒前
华仔应助科研通管家采纳,获得10
14秒前
SciGPT应助科研通管家采纳,获得10
14秒前
14秒前
一团小煤球完成签到,获得积分10
14秒前
14秒前
NexusExplorer应助科研通管家采纳,获得10
14秒前
14秒前
14秒前
卡乐瑞咩吹可完成签到,获得积分10
14秒前
田様应助科研通管家采纳,获得10
14秒前
苦咖啡行僧完成签到 ,获得积分10
14秒前
鹤鸣完成签到,获得积分10
15秒前
守望阳光1完成签到,获得积分10
15秒前
正直天空发布了新的文献求助10
15秒前
17秒前
YU发布了新的文献求助10
17秒前
大方元风完成签到 ,获得积分10
17秒前
高分求助中
【提示信息,请勿应助】关于scihub 10000
Les Mantodea de Guyane: Insecta, Polyneoptera [The Mantids of French Guiana] 3000
徐淮辽南地区新元古代叠层石及生物地层 3000
The Mother of All Tableaux: Order, Equivalence, and Geometry in the Large-scale Structure of Optimality Theory 3000
Global Eyelash Assessment scale (GEA) 1000
Picture Books with Same-sex Parented Families: Unintentional Censorship 550
Research on Disturbance Rejection Control Algorithm for Aerial Operation Robots 500
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 4038388
求助须知:如何正确求助?哪些是违规求助? 3576106
关于积分的说明 11374447
捐赠科研通 3305798
什么是DOI,文献DOI怎么找? 1819322
邀请新用户注册赠送积分活动 892672
科研通“疑难数据库(出版商)”最低求助积分说明 815029