石墨烯
材料科学
插层(化学)
电化学
检出限
纳米技术
制作
X射线光电子能谱
拉曼光谱
电极
化学工程
无机化学
色谱法
化学
替代医学
物理化学
病理
工程类
物理
光学
医学
出处
期刊:FlatChem
[Elsevier]
日期:2022-05-01
卷期号:33: 100353-100353
被引量:6
标识
DOI:10.1016/j.flatc.2022.100353
摘要
Tuning of the electronic and surface properties of the graphene via novel strategy is highly desirable issue for the fabrication of multifunctional materials in potential sensing applications. In this study, we synthesized the extremely pure graphene nanosheets (M−GRNs) by metal intercalation approach in a bulk form, and followed by the fabrication of a portable electrochemical sensing platform prepared on screen-printed carbon electrode (SPCE). The superiority of M−GRNs in terms of the electrocatalytic performance has been confirmed by the comparison with graphene nanosheets synthesized via conventional chemical reduction route. Raman, XPS and TEM techniques were utilized to verify the structure and morphology of the prepared graphene samples. The electrochemical performance of the fabricated M−GRNs/SPCE was evaluated by various voltammetric techniques towards the anticancer agent pemetrexed (PMX) as a model target analyte. The results reveal that M−GRNs/SPCE exhibited an outstanding electrochemical performance with a linear working range of 0.05–2.2 µM (R2=0.9915) and challenging detection limit of 9.7 nM towards the electro-oxidation of PMX. The detection of PMX in human serum samples was successfully analyzed at M−GRNs/SPCE with satisfactory recoveries. The possible interaction mechanism of PMX with double-stranded DNA on M−GRNs/SPCE has been also discussed. This proposed strategy could be an alternative to produce the sensitive graphene-based platforms for electroanalytical applications in clinical samples.
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