CTL公司*
宫颈癌
细胞毒性T细胞
免疫疗法
人类白细胞抗原
癌症
克隆(Java方法)
癌症研究
表位
医学
癌症免疫疗法
热休克蛋白
免疫学
肽
细胞毒性
结直肠癌
抗原
肽疫苗
生物
内科学
CD8型
体外
生物化学
DNA
基因
作者
Kazuto Nosaka,Shiro Suzuki,Toshiaki Yoshikawa,Manami Shimomura,Kazuhisa Kitami,Kosuke Yoshida,Masato Yoshihara,Fumitaka Kikkawa,Tetsuya Nakatsura,Hiroaki Kajiyama
出处
期刊:Anticancer Research
[Anticancer Research USA Inc.]
日期:2021-09-30
卷期号:41 (10): 4741-4751
被引量:2
标识
DOI:10.21873/anticanres.15289
摘要
Background/Aim: Heat shock protein 105 (HSP105) is overexpressed in various cancers, but not in normal tissues. We investigated the expression levels of HSP105 in cervical cancer and the efficacy of immunotherapy targeting HSP105. Materials and Methods: Previously, we established human leukocyte antigen-A*02:01 (HLA-A2) restricted HSP105 peptide-specific cytotoxic T lymphocyte (CTL) clones from a colorectal cancer patient vaccinated with an HSP105 peptide. Herein, we evaluated the expression of HSP105 in cervical cancer and cervical intraepithelial neoplasia. Moreover, we tested the effectiveness of an HLA-A2-restricted HSP105 peptide-specific CTL clone against cervical cancer cell lines. Results: HSP105 was expressed in 95% (19/20) of examined cervical cancer tissues. Moreover, the HSP105 peptide-specific CTL clone recognized HSP105- and HLA-A*02:01-positive cervical cancer cell lines and also showed that cytotoxicity against the cervical cancer cell lines depends on HSP105 peptide and HLA class I restricted manners. Conclusion: HSP105 could be an effective target for immunotherapy in patients with cervical cancer.
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