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Wound healing properties of triple cross-linked poly (vinyl alcohol)/methacrylate kappa-carrageenan/chitooligosaccharide hydrogel

乙烯醇 生物相容性 自愈水凝胶 甲基丙烯酸酯 伤口愈合 复合数 伤口敷料 材料科学 生物医学工程 甲基丙烯酸甲酯 卡拉胶 体内 化学 复合材料 高分子化学 共聚物 外科 有机化学 聚合物 医学 生物技术 生物 生物化学
作者
Pathum Chandika,Min‐Sung Kim,Fazlurrahman Khan,Young‐Mog Kim,Seong‐Yeong Heo,Gun‐Woo Oh,Nam Gyun Kim,Won‐Kyo Jung
出处
期刊:Carbohydrate Polymers [Elsevier BV]
卷期号:269: 118272-118272 被引量:69
标识
DOI:10.1016/j.carbpol.2021.118272
摘要

To develop an effective and mechanically robust wound dressing, a poly (vinyl alcohol) (PVA)/methacrylate kappa-carrageenan (κ-CaMA) composite hydrogel encapsulated with a chitooligosaccharide (COS) was prepared in a cassette via repeated freeze/thaw cycles, photo-crosslinking, and chemical cross-linking. The chemical, physical, mechanical, in vitro biocompatibility, in vivo wound-healing properties, and antibacterial activity of triple-crosslinked hydrogel were subsequently characterized. The results showed that the PVA/κ-CaMA/COS (Pκ-CaC) hydrogel had a uniformly thick, highly porous three-dimensional architecture with uniformly distributed pores, a high fluid absorption, and retention capacity without disturbing its mechanical stability, and good in vitro biocompatibility. Macroscopic images from the full-thickness skin wound model revealed that the wounds dressed with the proposed Pκ-CaC hydrogel were completely healed by day 14, while the histomorphological results confirmed full re-epithelization and rapid skin-tissue remodeling. This study thus indicates that the composite Pκ-CaC hydrogel has significant potential for use as a wound dressing. • Photo-crosslinkable methacrylated kappa-carrageenan was successfully synthesized. • Triple cross-linked composite hydrogel wound dressings were prepared. • Physically, mechanically and biologically compatible hydrogels were obtained. • The composite hydrogel accelerated the full-thickness excision skin wound closure. • Histomorphological results confirmed rapid skin-tissue remodeling.
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