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Lysophosphatidylcholine exerts an anti‐skin photoaging effect via heat shock protein 70 induction

哈卡特 活力测定 小眼畸形相关转录因子 黑色素 光老化 化学 热休克蛋白70 酪氨酸酶 分子生物学 光毒性 药理学 体外 热休克蛋白 皮肤病科 生物化学 医学 生物 基因
作者
Hyunmin Hwang,Hyeyeon Chun,Dae‐Hyun Kim,Munju Shin,Yun‐Sun Kim,Sohyun In,Tae‐Yoon Kim,Nae Gyu Kang
出处
期刊:Journal of Cosmetic Dermatology [Wiley]
卷期号:20 (12): 4060-4067 被引量:5
标识
DOI:10.1111/jocd.14068
摘要

Skin-brightening agents prevent melanogenesis and reduce melanin production. However, a lower melanin content leads to weaker protection against sunlight. In this study, we evaluated the effect of lysophosphatidylcholine (LPC) and its commercial-grade product, Lysofix Dry™ (LD), on heat shock protein 70 (HSP70) expression in epidermal cells and their anti-skin photoaging effect against ultraviolet B (UVB) and blue light.The HSP70 induction was detected using ELISA. To confirm the inhibition of melanin synthesis by LPC or LD, the melanin content assay and gene expression were analyzed. Cell viability was assessed to verify whether LPC or LD prevents photo-induced skin damage. The split-face test was performed to confirm skin-brightening effect of LD. Cream formulation with 2% of LD and placebo were used for 8 weeks, and skin brightness (L) was measured with chromameter (CR-400, Konica Minolta).LPC- and LD-induced HSP70 expression in epidermal cells. LPC and LD effectively suppressed melanogenesis provoked by α-MSH in B16 cells. They also inhibited the mRNA transcription of MITF and tyrosinase under blue light irradiation. LD increased the viability of B16 and HaCaT cells after UVB and blue light irradiation in vitro. The cream containing 2% LD increased ΔL by 1.7 after 8 weeks of use, whereas the placebo led to an increase of 0.7.LPC and LD were effective in suppressing melanogenesis and enhancing cell viability under UVB and blue light via HSP70 expression. Thus, they can be considered as potent skin-brightening agents with protective effects against skin photoaging.

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