[Therapeutic effect of mucopolysaccharide polysulfate cream in prevention of postoperative scars].

To assess the therapeutic effect of mucopolysaccharide polysulfate cream in prevention of postoperative scars. Methods: One hundred postoperative patients were divided into an experimental group and a control group (each n=50). After stitch removal, the experimental group wiped mucopolysaccharide polysulfate cream, and the control group wiped urea cream. The scars of the two groups were evaluated by Vancouver Scar Scale (VSS) on the day of stitch removal and in the 4th, 8th, 12th, 16th, 20th, 24th, 28th, and 32th weeks during the treat process. Results: At the beginning of treatment, the total VSS scores in the experimental group were always lower than that in the control group (P<0.05). There was no difference between the two groups in the color scores at each time point of follow-up (P>0.05). Form the 20th week, the vascular distribution scores in the experimental group were lower than that in the control group (P<0.05). And the thickness and flexibility scores in the experimental group were lower at each time point of follow-up (P<0.05). There were no differences between the two groups in wounds in head, face, or neck in the total VSS scores and all index scores (P>0.05), and the total VSS scores in the experimental group, who had wounds in chest, shoulder, or back, or had wounds in waist, abdomen, or hip, or had wounds in extremity, were lower than that in the control group (P<0.05). The vascular distribution and thickness scores in the experimental group, who had wounds in chest, shoulder, or back, were better than that in the control group (P<0.05). Conclusion: Wiping mucopolysaccharide polysulfate cream after operation as soon as possible can effectively prevent scar hyperplasia, and it is worth to be widely applied in clinic.目的：评估使用多磺酸黏多糖乳膏预防术后瘢痕的疗效。方法：以100例手术后患者为研究对象，分为实验组(伤口拆线后第2天予以多磺酸黏多糖乳膏外涂)和对照组(伤口拆线后第2天予以尿素乳膏外涂)，每组50人。以温哥华瘢痕量表(VSS)为依据，分别在伤口拆线当日及治疗开始后的第4，8，12，16，20，24，28，32周对患者进行瘢痕评估。结果：治疗开始后，实验组每次随访的VSS总评分均较低(P<0.05)；实验组的色泽评分与对照组各个随访时点比较，差异均无统计学意义(P>0.05)；实验组血管分布评分于第20周开始较对照组明显降低(P<0.05)；实验组厚度和柔软度评分在治疗开始后的各个随访时点均显著低于对照组(P<0.05)。其中，伤口在头面颈部位的实验组无论是VSS总评分还是VSS各项指标评分，与对照组比较，差异均无统计学意义(P>0.05)，而伤口在胸肩背、腰腹臀或四肢部位的实验组VSS总评分均较相应的对照组明显降低(P<0.05)。伤口在胸肩背部位的实验组血管分布、厚度评分较相应的对照组明显改善(P<0.05)。结论：术后及早局部外用多磺酸黏多糖可有效预防瘢痕增生，值得在临床上推广。.