Associations between Blood Cell Profiles and Primary Open-Angle Glaucoma: A Retrospective Case-Control Study

医学 内科学 胃肠病学 淋巴细胞 接收机工作特性 青光眼 开角型青光眼 眼科 中性粒细胞与淋巴细胞比率
作者
Binghua Tang,Shengjie Li,Jianping Han,Wenjun Cao,Xinghuai Sun
出处
期刊:Ophthalmic Research [S. Karger AG]
卷期号:63 (4): 413-422 被引量:24
标识
DOI:10.1159/000504450
摘要

<b><i>Purpose:</i></b> We aimed to evaluate whether the neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), lymphocyte-to-monocyte ratio (LMR), and systemic immune inflammation index (SII) were associated with primary open-angle glaucoma (POAG). <b><i>Materials and Methods:</i></b> This retrospective case-control study included 240 patients with POAG and 300 age- and sex-matched control subjects. Complete ophthalmological examination and blood count measurements were performed for all subjects. <b><i>Results:</i></b> The values of NLR, PLR, and SII in the POAG group were significantly increased compared with the control group (<i>p</i> &#x3c; 0.001; <i>p</i> = 0.012; <i>p</i> &#x3c; 0.001). However, the LMR value was lower in the POAG patients than in the control group (<i>p</i> &#x3c; 0.001). When we divided the subjects into different age and gender subgroups, the NLR and SII values in the POAG patients were always higher than those in the control group. In the comparison of laboratory parameters in POAG subjects stratified according to severity, we also found that NLR and SII increased with the severity. The receiver operating characteristic (ROC) analysis revealed that the areas under the ROC curve of NLR, PLR, LMR, and SII to predict patients with POAG were found to be 0.627, 0.569, 0.382, and 0.986, respectively. The best cutoff point of NLR was 1.998 with a sensitivity of 59.8% and a specificity of 63.0%, and the SII was 947.365 with a sensitivity of 95.4% and a specificity of 95.7%. Multivariable logistic regression analysis showed that NLR was positively associated with mean deviation; moreover, NLR and SII were independent indicators correlated with POAG (OR 1.502; 95% CI 1.227–1.839; <i>p</i> &#x3c; 0.001; OR 1.02; 95% CI 1.009–1.021; <i>p</i> &#x3c; 0.001). <b><i>Conclusion:</i></b> We speculated that elevated NLR and SII might serve as readily available inflammatory predictors in POAG patients.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
大幅提高文件上传限制,最高150M (2024-4-1)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
1秒前
jjx1005完成签到 ,获得积分10
2秒前
Akim应助黄蛋黄采纳,获得10
4秒前
yangching应助樱桃小王子采纳,获得10
4秒前
Emper发布了新的文献求助10
4秒前
push完成签到 ,获得积分10
6秒前
冰糖葫芦不加糖完成签到 ,获得积分10
14秒前
couletian完成签到 ,获得积分10
15秒前
赫连又蓝发布了新的文献求助30
16秒前
英俊的铭应助坦率雁卉采纳,获得10
17秒前
18秒前
TY完成签到 ,获得积分10
19秒前
20秒前
22秒前
黄蛋黄完成签到,获得积分10
24秒前
25秒前
Cloud驳回了Akim应助
25秒前
无尘发布了新的文献求助10
27秒前
28秒前
30秒前
坚强热狗发布了新的文献求助10
33秒前
34秒前
ljcznhy完成签到,获得积分10
35秒前
叡叡发布了新的文献求助10
37秒前
39秒前
8R60d8应助科研通管家采纳,获得10
40秒前
深情安青应助科研通管家采纳,获得10
40秒前
8R60d8应助科研通管家采纳,获得10
40秒前
领导范儿应助科研通管家采纳,获得10
40秒前
40秒前
JamesPei应助科研通管家采纳,获得10
41秒前
田様应助科研通管家采纳,获得10
41秒前
香蕉觅云应助科研通管家采纳,获得10
41秒前
所所应助科研通管家采纳,获得10
41秒前
Hello应助科研通管家采纳,获得10
41秒前
Singularity应助科研通管家采纳,获得10
41秒前
8R60d8应助科研通管家采纳,获得10
41秒前
Singularity应助科研通管家采纳,获得10
41秒前
41秒前
Singularity应助科研通管家采纳,获得10
41秒前
高分求助中
Evolution 10000
ISSN 2159-8274 EISSN 2159-8290 1000
Becoming: An Introduction to Jung's Concept of Individuation 600
Ore genesis in the Zambian Copperbelt with particular reference to the northern sector of the Chambishi basin 500
A new species of Coccus (Homoptera: Coccoidea) from Malawi 500
A new species of Velataspis (Hemiptera Coccoidea Diaspididae) from tea in Assam 500
PraxisRatgeber: Mantiden: Faszinierende Lauerjäger 500
热门求助领域 (近24小时)
化学 医学 生物 材料科学 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 基因 遗传学 催化作用 物理化学 免疫学 量子力学 细胞生物学
热门帖子
关注 科研通微信公众号,转发送积分 3161827
求助须知:如何正确求助?哪些是违规求助? 2813059
关于积分的说明 7898411
捐赠科研通 2472080
什么是DOI,文献DOI怎么找? 1316331
科研通“疑难数据库(出版商)”最低求助积分说明 631278
版权声明 602129