清晨好,您是今天最早来到科研通的研友!由于当前在线用户较少,发布求助请尽量完整的填写文献信息,科研通机器人24小时在线,伴您科研之路漫漫前行!

Associations between Blood Cell Profiles and Primary Open-Angle Glaucoma: A Retrospective Case-Control Study

医学 内科学 胃肠病学 淋巴细胞 接收机工作特性 青光眼 开角型青光眼 眼科 中性粒细胞与淋巴细胞比率
作者
Binghua Tang,Shengjie Li,Jianping Han,Wenjun Cao,Xinghuai Sun
出处
期刊:Ophthalmic Research [S. Karger AG]
卷期号:63 (4): 413-422 被引量:24
标识
DOI:10.1159/000504450
摘要

<b><i>Purpose:</i></b> We aimed to evaluate whether the neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), lymphocyte-to-monocyte ratio (LMR), and systemic immune inflammation index (SII) were associated with primary open-angle glaucoma (POAG). <b><i>Materials and Methods:</i></b> This retrospective case-control study included 240 patients with POAG and 300 age- and sex-matched control subjects. Complete ophthalmological examination and blood count measurements were performed for all subjects. <b><i>Results:</i></b> The values of NLR, PLR, and SII in the POAG group were significantly increased compared with the control group (<i>p</i> &#x3c; 0.001; <i>p</i> = 0.012; <i>p</i> &#x3c; 0.001). However, the LMR value was lower in the POAG patients than in the control group (<i>p</i> &#x3c; 0.001). When we divided the subjects into different age and gender subgroups, the NLR and SII values in the POAG patients were always higher than those in the control group. In the comparison of laboratory parameters in POAG subjects stratified according to severity, we also found that NLR and SII increased with the severity. The receiver operating characteristic (ROC) analysis revealed that the areas under the ROC curve of NLR, PLR, LMR, and SII to predict patients with POAG were found to be 0.627, 0.569, 0.382, and 0.986, respectively. The best cutoff point of NLR was 1.998 with a sensitivity of 59.8% and a specificity of 63.0%, and the SII was 947.365 with a sensitivity of 95.4% and a specificity of 95.7%. Multivariable logistic regression analysis showed that NLR was positively associated with mean deviation; moreover, NLR and SII were independent indicators correlated with POAG (OR 1.502; 95% CI 1.227–1.839; <i>p</i> &#x3c; 0.001; OR 1.02; 95% CI 1.009–1.021; <i>p</i> &#x3c; 0.001). <b><i>Conclusion:</i></b> We speculated that elevated NLR and SII might serve as readily available inflammatory predictors in POAG patients.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
大幅提高文件上传限制,最高150M (2024-4-1)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
司空天德发布了新的文献求助10
1秒前
积极冷松完成签到 ,获得积分10
2秒前
victory_liu完成签到,获得积分10
3秒前
L_x完成签到 ,获得积分10
26秒前
26秒前
TTTHANKS完成签到 ,获得积分10
29秒前
聂立双完成签到 ,获得积分10
30秒前
平常从蓉发布了新的文献求助10
33秒前
郑雅柔完成签到 ,获得积分10
34秒前
娇娇大王完成签到,获得积分10
38秒前
Binbin完成签到 ,获得积分10
44秒前
斯文败类应助john采纳,获得10
49秒前
WXM完成签到 ,获得积分10
49秒前
mia完成签到,获得积分10
55秒前
wujiwuhui完成签到 ,获得积分10
1分钟前
Huang完成签到 ,获得积分0
1分钟前
Jessica完成签到,获得积分10
1分钟前
TT完成签到,获得积分10
1分钟前
candice624完成签到 ,获得积分10
1分钟前
研友_西门孤晴完成签到,获得积分10
1分钟前
1分钟前
H_C发布了新的文献求助10
1分钟前
平常向雪发布了新的文献求助10
1分钟前
法外潮湿宝贝完成签到 ,获得积分10
1分钟前
1分钟前
宸浅完成签到 ,获得积分10
1分钟前
fzh发布了新的文献求助10
1分钟前
dream完成签到 ,获得积分10
1分钟前
fzh完成签到,获得积分10
1分钟前
木光完成签到,获得积分20
2分钟前
科研通AI2S应助Singularity采纳,获得10
2分钟前
砳熠完成签到 ,获得积分10
2分钟前
葫芦芦芦完成签到 ,获得积分10
2分钟前
sunny完成签到 ,获得积分10
2分钟前
完美青柏完成签到 ,获得积分10
2分钟前
毛豆爸爸完成签到 ,获得积分0
2分钟前
小羊完成签到,获得积分10
2分钟前
荔枝波波加油完成签到 ,获得积分10
2分钟前
TTTHANKS发布了新的文献求助10
2分钟前
2分钟前
高分求助中
Sustainability in Tides Chemistry 1500
TM 5-855-1(Fundamentals of protective design for conventional weapons) 1000
Gerard de Lairesse : an artist between stage and studio 500
Digging and Dealing in Eighteenth-Century Rome 500
Queer Politics in Times of New Authoritarianisms: Popular Culture in South Asia 500
Livre et militantisme : La Cité éditeur 1958-1967 500
Retention of title in secured transactions law from a creditor's perspective: A comparative analysis of selected (non-)functional approaches 500
热门求助领域 (近24小时)
化学 医学 生物 材料科学 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 基因 遗传学 催化作用 物理化学 免疫学 量子力学 细胞生物学
热门帖子
关注 科研通微信公众号,转发送积分 3063230
求助须知:如何正确求助?哪些是违规求助? 2717989
关于积分的说明 7456754
捐赠科研通 2364300
什么是DOI,文献DOI怎么找? 1253400
科研通“疑难数据库(出版商)”最低求助积分说明 608585
版权声明 596606