医学
内科学
胃肠病学
淋巴细胞
接收机工作特性
青光眼
开角型青光眼
眼科
中性粒细胞与淋巴细胞比率
作者
Binghua Tang,Shengjie Li,Jianping Han,Wenjun Cao,Xinghuai Sun
出处
期刊:Ophthalmic Research
[S. Karger AG]
日期:2020-01-01
卷期号:63 (4): 413-422
被引量:24
摘要
<b><i>Purpose:</i></b> We aimed to evaluate whether the neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), lymphocyte-to-monocyte ratio (LMR), and systemic immune inflammation index (SII) were associated with primary open-angle glaucoma (POAG). <b><i>Materials and Methods:</i></b> This retrospective case-control study included 240 patients with POAG and 300 age- and sex-matched control subjects. Complete ophthalmological examination and blood count measurements were performed for all subjects. <b><i>Results:</i></b> The values of NLR, PLR, and SII in the POAG group were significantly increased compared with the control group (<i>p</i> < 0.001; <i>p</i> = 0.012; <i>p</i> < 0.001). However, the LMR value was lower in the POAG patients than in the control group (<i>p</i> < 0.001). When we divided the subjects into different age and gender subgroups, the NLR and SII values in the POAG patients were always higher than those in the control group. In the comparison of laboratory parameters in POAG subjects stratified according to severity, we also found that NLR and SII increased with the severity. The receiver operating characteristic (ROC) analysis revealed that the areas under the ROC curve of NLR, PLR, LMR, and SII to predict patients with POAG were found to be 0.627, 0.569, 0.382, and 0.986, respectively. The best cutoff point of NLR was 1.998 with a sensitivity of 59.8% and a specificity of 63.0%, and the SII was 947.365 with a sensitivity of 95.4% and a specificity of 95.7%. Multivariable logistic regression analysis showed that NLR was positively associated with mean deviation; moreover, NLR and SII were independent indicators correlated with POAG (OR 1.502; 95% CI 1.227–1.839; <i>p</i> < 0.001; OR 1.02; 95% CI 1.009–1.021; <i>p</i> < 0.001). <b><i>Conclusion:</i></b> We speculated that elevated NLR and SII might serve as readily available inflammatory predictors in POAG patients.
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