光敏剂
单线态氧
纳米棒
光动力疗法
材料科学
荧光
量子产额
水溶液
光化学
纳米颗粒
纳米技术
聚集诱导发射
纳米结构
泊洛沙姆
共聚物
化学
有机化学
聚合物
氧气
复合材料
物理
量子力学
作者
Wenkun Han,Song Zhang,Rong Deng,Yangyang Du,Jingyu Qian,Xiaohua Zheng,Bin Xu,Zhigang Xie,Fei Yan,Wenjing Tian
标识
DOI:10.1007/s40843-019-9477-3
摘要
Three nanostructured photosensitizers with aggregation-induced emission (AIE) characteristics based on 2,3-bis(4′-(diphenylamino)-[1,1′-biphenyl]-4-yl) fumaronitrile (BDBF) were prepared for image-guided photodynamic therapy (PDT). BDBF was encapsulated with Pluronic F-127 (F127) to form usual spherical nanoparticles (F127@BDBF NPs) with a red fluorescence emission and 9.8% fluorescence quantum yield (FQY). Moreover, BDBF self-assembled into nanorods (BDBF NRs) in water. Compared with F127@BDBF NPs, BDBF NRs exhibited stronger orange fluorescence with a higher FQY of 23.3% and similar singlet oxygen (1O2) generation capability. BDBF NRs were further modified with F127 to form BDBF@F127 NRs with the same 1O2 generation ability as BDBF NRs. The three nanostructures exhibited a higher 1O2 production capacity than BDBF molecule in dissolved state and favorable stability in an aqueous solution as well as under physiological condition. In vitro photocytotoxicity experiments indicated that the three nanostructures inhibited tumor cell proliferation effectively. Therefore, to construct eligible nanostructures with a high FQY and 1O2 generation ability, simple self-assembly can serve as a valuable method to prepare photosensitizers with enhanced PDT.
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