未折叠蛋白反应
内质网
发病机制
程序性细胞死亡
细胞生物学
细胞凋亡
生物
细胞
细胞器
免疫学
遗传学
作者
Benjamin G. Spencer,John W. Finnie
标识
DOI:10.1016/j.jcpa.2020.10.006
摘要
It is now increasingly recognized that endoplasmic reticulum (ER) stress, which is caused by the accumulation of overproduced or misfolded proteins in this organelle, contributes to the pathogenesis of a diverse range of human diseases. ER stress initiates the unfolded protein response (UPR) in an attempt to restore cellular protein homeostasis and promote cell survival. However, when ER stress is severe or protracted, and uncompensated, the UPR can fail, resulting in cell death, often by apoptosis. ER stress has received relatively little attention in the veterinary literature and the intent of this mini review is to describe the essential features of ER stress and UPR in determining the survival or demise of an affected cell and encourage further study of its role in the pathogenesis of diseases of domestic animal species. The role of ER stress, particularly when chronic and unrelieved, in the pathogenesis of a number of specific diseases is also discussed.
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